Polynucleotides FAQ 

What are polynucleotides?

DNA and RNA are two examples of polynucleotides. The polynucleotides used in cosmetic medicine to remodel the skin are made up of highly purified fragments of DNA extracted from wild salmon or trout sperm. The trout used are the same as used for food. Salmon and trout sperm DNA closely resembles human DNA.

Is it safe?

The polynucleotides are highly purified and then sterilised from a licensed source, the production is regulated and the manufacture meets required CE standards of safety. All the protein molecules are removed, so there is no risk of allergy. The science is evidenced based and there are multiple published scientific papers demonstrating safety and efficacy in medicine for the treatment of tissue injury and also in aesthetic medicine. There are no known risks associated with the injection of exogenous (Non-self) polynucleotides. We can explain the temporary side-effects you may experience.

What can they treat?

• Dull skin
• Course skin
• Wrinkles
• Uneven Pigmentation
• Redness
• Dark circles
• Acne scarring>
• Stretch marks
• Surgical scarring
• Hair loss
• Not just for the face; hands, neck, chest, arms, knees. Any skin, anywhere on the body.

How do they work?

Polynucleotides stimulate a receptor on cells which positively influences the following
• Cell proliferation
• The repair and regenerative actions of fibroblast cells
• The production of collagen and elastin
• The production of hyaluronic acid
• The production of healthy new micro-blood vessels
• The function of melanocytes which produce pigment.
• They reduce inflammation
• Regulate water balance
• Regulate the formation of fat cells
• Regenerate hair follicles The use of polynucleotides in regenerative medicine is well established in tissue repair, following traumatic injury or surgery

What does treatment involve?

The polynucleotides are distilled into a range of strengths and suspended in water for injection. They are injected into the superficial layer of the skin. The clinician uses either a fine needle or a cannula to administer multiple micro-doses into the target area. A course of three or four treatments 3 weeks apart is recommended to achieve optimum results.

What results can I expect?

The results are not instant but improvement can be noted from about three weeks and continues to improve over a twelve week period. Patients report a general improvement in the radiance of the skin, the skin should feel smoother and better hydrated. Pores and uneven colouration and texture can be improved. Fine lines and wrinkles are improved. Scarring can be improved, with less depth, smaller and better colour.
When hair loss is the concern being addressed, new hair growth can be noted and existing hair will be healthier. Results will vary between individuals as the outcome is dependent upon the biological response of the individual and also lifestyle factors.

How long do results last?

Longevity does vary between individuals. Polynucleotides do not arrest the ageing process, therefore a maintenance treatment is recommended every six months. Life-style factors can effect longevity. If you choose not to maintain the results with further treatment, your skin will return to its pre-treatment state over time.


Because bruising and swelling can occur and may take time to settle, it is not advisable to have treatment just before an important event. Although the majority of patients suffer only minor side effects related to the injections, it is best to allow sufficient time for any possible side effects to resolve. For 12-24 hours you may have visible bumps in the skin. Pin prick marks/scabs may take 5 days to resolve. Bruising can take up to 2 weeks to resolve. Though make-up can be worn the next day. Your clinician will advise. Do not schedule treatment when you have other procedures or medical treatments planned, without first discussing with your clinician. This includes, but is not limited to; vaccinations, massage, facials, dental appointments and surgery.
It is best not to schedule treatment just before a holiday in the sun.

Am I suitable for treatment?

We will take a detailed medical history to ensure you have no conditions that might increase risk of unwanted side effects, consultation is also important to discuss your expectations and whether this treatment is able to meet them.

Does it hurt?

Treatment can be uncomfortable. A topical anaesthetic cream will be applied before treatment to numb the skin.
How to prepare for treatment? Do read all the information provided to you and highlight anything you need to ask about. Check the clinic terms and conditions before attending.
All make-up will need to be removed prior to treatment, so please come ‘fresh faced’ if possible.
Check medicines and supplements
Aspirin, Ibuprofen and a range of dietary supplements including St. John’s Wort, fish oils, Ginkgo Biloba, Vitamins C and E- may all contribute to bruising and are best avoided 24 hours before treatment.
Don’t drink alcohol the night before, it will increase your risk of bruising.
Healthy skin and feeling well?
Check with us before attending if any of the following apply
• Cold sore, brewing, active or recent and not quite healed.
• Acne break-out
• Feeling unwell- including colds, coughs, sore throats etc.
• New diagnosis or medicines
• New injury for which you are taking pain medicines
• Appointments with the dentist; recent, or planned within 10 days of the treatment
• Travel plans within 10 days of the treatment.
Bring your reading glasses with you.
You will need to read and sign some forms
Patient tips and tricks
Sunglasses are useful to hide treatment around the eyes after treatment. Silk scarves or polo necks for treatment on the neck.
Leave jewellery at home, especially large earrings, or facial piercings, bring a purse to keep them safely if you have to remove them.

What is the aftercare?

You may continue with normal activities, but it is likely there will be small bumps just under the skin that will be visible and may take from 3-12 hours to settle. It is possible you will have some redness, pin prick marks, possibly swelling. Possibly bruising. Swelling is likely to settle within 48 hours. Bruising may be more apparent the next day and can take up to 10-14 days to resolve.

For 6 hours

To avoid infection;
• Do not reapply make-up
• Do not wear tight head-gear such as bike or cycle helmets, or riding hats. These will not be clean and may increase risk of infection.
• Keep your hands clean and avoid touching your face
• Avoid using your mobile phone against the treated area
• Don’t let pets lick your face
• Don’t pick or scratch the treated area.

For 12-24 hours

It is advisable to avoid aspirin and alcohol which can make any swelling or bruising worse

Until any redness, swelling or bruising has settled

To minimise discomfort and help it settle;
Avoid extremes of heat or cold or vigorous exercise, until any swelling, bruising or tenderness has settled.
Swelling may worsen in the first 24 hours, and then should settle within the first few days. Cold packs can be helpful in reducing swelling. Be sure not to apply ice directly to the skin or for too long. This can cause a ‘freeze burn’.
Bruising may take a few days to appear, arnica or bromelain can be helpful in clearing bruising. Tenderness should settle as swelling goes down.
If you have any symptoms which concern you or get worse rather than better after 12 hours please don’t hesitate to contact the clinic for further advice.
Please make sure you have booked your follow-up treatment in 3 weeks’ time, or as advised by your clinician.